The Slaton sisters averaging over a thousand pounds, have always depended on each other for support. Now in their 30s, Amy wants to have children, but cannot due to her weight, while her elder sister Tammy is near bedridden.

With her weight spiraling, Tammy makes the game-changing decision to check herself into rehab for food addiction, but her stay there may be short-lived as she considers the best way to reach her goals. She also appears to be talking to a new love interest, which is cause for concern for her family, as relationships have hindered Tammy's progress in the past. Amy is dealing with her own stress, and while her dreams came true when she became a mom to son Gage, balancing the demands of motherhood with her own weight-loss goals may prove to be impossible. Meanwhile, the sisters' brother Chris had reached the goal Dr. Smith set for him to be eligible for bariatric surgery but after a setback following a procedure to remove a boil from his leg, he fears he has blown his chances for life-saving surgery. Facing another check-up with their doctor, Tammy and Chris must both face the music and see whether their progress qualifies them for weight-loss surgery.

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