Adam Ruins Everything is based on a CollegeHumor web series of the same name, and stars comedian Adam Conover. Each episode begins with an ordinary person going about their daily lives before stating a common misconception regarding a certain topic. Usually the person in question is recurring cast member, comedian Emily Axford. Adam appears seemingly out of nowhere and introduces himself, and informs the other character and the audience about the misconceptions related to the character's statement. This dialogue serves as a springboard to a more in-depth discussion of commonly-held beliefs and falsehoods related to that topic, in which Adam provides historical background to explain how the ideas in question became popularized, introducing real-life experts who explain these details, and citing peer-reviewed science studies and other empirical sources from which the information is derived. When he does this, the citations briefly appear onscreen. This information is presented via the use of sketch characters, time travel, and animated segments, sometimes to the annoyance of the other character. At the end of the show's third act, the other characters' frustration will reach a critical point, prompting them to feel demoralized and disempowered. In the fourth act, however, Adam responds with a "positive takeaway", explaining how the new knowledge that has been provided can provide a solution to the situation, and explaining how the characters and views can do their part to improve society and their lives.

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